The Journal of Restorative Medicine has published an article by Dr. Edward Lichen in their December 2016 compilation about non-surgical treatment of Endometriosis. You can read the article, in it’s entirety, by clicking on the link under “Resources,” but I wanted to give a brief overview of my interpretation:
- Causation continues to be a mystery. An overview of the nine theories of causation is given.
- DNA research is ongoing.
- Estrogen plays a role. Many women with Endometriosis cannot opt for estrogen replacement therapy (even if post-menopausal) due to high recurrence rates of estrogen stimulation.
- Xenoestrogens, dioxins, and endocrine disruptors increase inflammation and can cause Endometriosis to develop/recur.
Recurrence After Surgery:
- There’s a 10% recurrence rate in less-severe Endometriosis.
- There’s a 62% recurrence rate in women with severe Endometriosis who still have their ovaries. Keeping the ovaries may lead to a 6 times greater risk of recurrent pain and an 8 times greater risk of recurrent surgery.
- 20%-40% of women who have had surgery continue to suffer from residual pain.
- 3.7% of women who undergo a hysterectomy and/or oophorectomy have have a recurrence of Endometriosis.
- The ideal pharmaceutical treatment of Endometriosis has yet to be developed.
- Lupron Depot, and other similar GnRH agonists, continue to remain the preferred method of symptom suppression, regardless of the side effects.
- Aromatase inhibotors, such as Letrozole, also have similar side effects and symptom relief as Lupron Depot.
- Danazol, a synthetic steroid, is the only alternative to GnRH agonists which offers similar symptom relief with fewer side effects.
- The use of add-back estrogen sometimes offers little relief from the side effects.
- Failure of these treatments often leads to surgery, hysterectomies, and oophorectomies.
- A drug combination of anabolic steroids, Nandrolone and Stanozolol, shows similar symptom suppression without the side effects of Lupron Depot or Danazol. A case study of one woman treating with both drugs has had symptom suppression and very few side effects over an eight-year period. (See US Doctor abstract under Resources).
What will you do with this new information? I may talk to my doctor about the steroids combo if my pain returns full-force…but only after doing my own research about the side effects one can expect from that cocktail!
(Updated March 27, 2019)
Journal of Restorative Medicine – (Article; Dec. 2016) Paradigm Shift: The Realization of New Medical Alternatives to Surgery for Endometriosis
US Doctor – (Poster; 2014) Novel Medical Endometriosis Protocol Offers Alternative to TAH BSO and Hemicolectomy in Confirmed Stage IV Disease
~ Again, I am a layman. I do not hold any college degrees, nor mastery of knowledge. Please take what I say with a grain of salt. If curious, do your own research Validate my writings. Or challenge them. And ALWAYS feel free to consult with your physician. Always. Yours ~ Lisa
One thought on “An alternative to Lupron Depot, Letrozole, or Danazol?”
Interesting ideas! I am a bit disappointed that dienogest (Visanne) only had a brief mention in the article though. Far as I know, it has been found to be as effective as Lupron, but with a lot less side-effects. The main side-effect of dienogest is breakthrough/abnormal bleeding, which, bothersome as it would be, cannot compare with the host of side-effects from Lupron! Also, I think it is the first drug that was specifically approved for endometriosis treatment in Europe?
LikeLiked by 1 person