In January of 2021, the Journal of Medical Primatology published an article about a hooded capuchin (a primate) that developed Endometriosis. They were able to “successfully” treat it with surgery and medical management.
This is only one case of a growing list of cases of spontaneous Endometriosis developing in non-humans: including several other primates and a dog. Animals with Endo break my heart: they cannot fully express any pain they may be in, or offer opinion or consent for medical procedures…and it just makes me want to weep.
Last year I wrote about a study involving Endometriosis being found in Cynomolgus monkeys. Recently, a new study was published in Human Reproduction about those monkeys and Endometriosis, and here I am to regurgitate it to you in my layman understanding.
At the Tsukuba Primate Research Center in Japan, 614 female cynomolgus monkeys were evaluated between 2008 and 2012. Of those, 29 were chosen to be screened on a routine basis, including monitoring menstrual cycles, fertility, bloodwork (including CA-125 levels), and physical examinations. Surgeries were performed and 15 of the 29 monkeys had surgically confirmed cases of Endometriosis.
Let me repeat that: fifteen of the 29 monkeys had surgically confirmed cases of Endometriosis. These monkeys were not implanted with Endometriosis as lab rats often are. It grew on its own.
These 15 monkeys ranged in age from 8 years old to 20 years old. They discovered that CA-125 levels tended to be elevated in the monkeys that had chocolate cysts present and lower in those who did not have endometriomas. They also discovered that painful palpation examinations and abnormal feces were both commonalities with these monkeys. Also of note, the monkeys ate less food during their menstrual cycles, which may be attributed to increased pain and a decreased quality of life.
During the time of the study, the remaining monkeys who did not have Endometriosis were monitored to make sure they did not develop the illness. Four of them DID develop Endometriosis!
Even though the monkeys were small in comparison to humans, the surgeons were able to easily identify Endometriosis lesions (and their various colors: red, pink, brown, blue, black or white), endometriomas (chocolate cysts), and adhesions while performing the laparoscopies.
Based on these findings, the authors suggest that screening, diagnosing, and monitoring Endometriosis in monkeys should include palpations, fecal monitoring, and CA-125 testing.
The findings of the study were that cynomolgus monkeys with spontaneous endometriosis may prove to be a good model to evaluate the disease, as well as drug efficacy. I would hate to think that that means they may one day end up as lab rats for drug companies. My animal-lovin’ brain takes me down that dark path, though.
I am constantly amazed by the presence of Endometriosis in non-humans. And saddened at the thought that these animals cannot vocalize the pain I know they feel. But knowing that the illness affects other species makes me hope that it may one day get the attention of the scientific and medical communities that it deserves.
RESOURCES:
Human Reproduction – (April 2018) – Spontaneous Endometriosis in Cynomolgus Monkeys as a Clinically Relevant Experiment Model (entire article)
~ Again, I am a layman. I do not hold any college degrees, nor mastery of knowledge. Please take what I say with a grain of salt. If curious, do your own research 😉 Validate my writings. Or challenge them. And ALWAYS feel free to consult with your physician. Always. Yours ~ Lisa
In the past, I’ve written about Endometriosis being found in two mandrillus sphinx, a German Shephard and cynomolgus monkeys. I know when I think of Endometriosis, I have to remind myself that any person, including cis-men can develop it, as well as animals. A study hit my inbox this morning about monkeys, rhesus macaques, developing Endometriosis.
The 2017 study published in Primate Biology discusses rhesus macaques (aka rhesus monkeys) that were housed at the Biomedical Primate Research Centre in the Netherlands and the New England Primate Research Center in the United States. Not only did the study discuss the spontaneous development of Endometriosis in these creatures, but it focused on the genetic similarities between humans and these monkeys in the hopes of continuing the studies of finding genetic links to the illness.
So, we recently wrote about Endometriosis being found in two mandrillus sphinx. Last year we learned about Endo being found in a German Shephard. Well, today we read about it being found in monkeys: cynomolgus monkeys. This is not the first time Endometriosis has been found in this breed of monkey, but we’re going to focus on just this new study today.
So we’ve previously read about a German Shepherd being diagnosed with Endometriosis. Today we’re going to talk about Mandrills (a form of primate that used to be considered a Baboon) who had been diagnosed with Endo. I’ve read a lot of previous studies where Endometriosis was purposely implanted into critters for study and dissection, but these primates weren’t for study.
There was a study from 2012 about a Mandrill that had died after showing signs of weakness and peritoneal bleeding. Upon autopsy they found her uterus was covered in blood clots and it was stuck to her ovaries and pelvic wall. The biopsy confirmed she had Endometriosis. This is considered the first confirmed case of Endo in a Mandrill.
Two weeks ago a paper was published in the Acta Veterinaria Scandinavica journal. The first reported case of an Endometrioma in a dog. A German Shepherd, to be precise. Now don’t be too surprised; primates have been found to develope endometriosis: gorillas, monkeys, and baboons. But this is the first time captured in literature that an animal has developed an Endometrioma. What’s that? A blood-filled cyst consistent with Endometriosis, sometimes referred to as a Chocolate Cyst.
Bloomin' Uterus 