LUPRON the worst experience in my life. My legs felt like knife sliced crackling twigs on a camp fire the first night of my needle. My hot flashes (day and night) have never gone away even after 21 years. The weight gain is impossible to get rid of. Arthritis is constant in most of my joints from my jaw, neck, shoulders elbows, lower back, hips, tailbone, knees, ankles, fingers and toes. I live with chronic pain everyday.