I took Lupron for 3 months after being diagnosed with severe endometriosis. I had not done any research prior to starting- boy, was that a mistake. Shortly after the first shot, I started having horrible hot flashes and night sweats (that persisted even with add back). Then came the fatigue, which I think was the worst of all. I would work my 8-5 and then come home and be knocked out all night. The bone pain was awful too. I hurt all the time EVERYWHERE! And then my hair started falling out. By that time I had enough and I switched doctors and discontinued lupron. My last lupron injection was just over a year ago. Since then, I had a total hysterectomy in September of last year. As far as residual, so far I really can’t say I notice anything except maybe my mind being a little foggy still. I am just so glad that I stopped when I did and now I don’t have to worry about it anymore!